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BiondVax Touts Additional Preclinical Data From Inhaled COVID-19 Treatment Candidate

  • BiondVax Pharmaceuticals Ltd BVXV announced additional results in a preclinical proof-of-concept study of its innovative inhaled NanoAb COVID-19 drug. 
  • The study compared weight loss in two groups of hamsters. Hamsters administered a mid-sized 0.66mg dose of the NanoAb three hours before infection experienced no significant weight loss over the six-day trial.
  • But the untreated control group’s weight declined 12% on average, a highly statistically significant difference.
  • The prophylactic results follow previously reported data from the same study indicating that compared to the control (placebo) group, hamsters treated with a 2mg dose of BiondVax’s inhaled NanoAb one day after infection had negligible SARS-CoV-2 viral titers in their lungs, and experienced a milder and shorter illness in comparison to the placebo group that had at least 30-times higher viral titers
  • This preclinical trial continues with additional arms testing lower therapeutic doses (0.66mg and 0.22mg). In 2023, BiondVax is expected to conduct a preclinical toxicity study. 
  • The company also expects to scale up its manufacturing processes for NanoAbs for the first-in-human Phase 1/2a trial, which is planned for Q4 2023.
  • Price Action: BVXV shares are up 2.55% at $2.82 on the last check Monday.

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